Tibemid
Brand names,
Tibemid
Analogs
Tibemid
Brand Names Mixture
Tibemid
Chemical_Formula
C19H24N2O3
Tibemid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Tibemid
fda sheet
Tibemid
msds (material safety sheet)
Tibemid
Synthesis Reference
No information avaliable
Tibemid
Molecular Weight
328.406 g/mol
Tibemid
Melting Point
195-196 oC
Tibemid
H2O Solubility
20 mg/ml (HCl salt)
Tibemid
State
Solid
Tibemid
LogP
2.868
Tibemid
Dosage Forms
Liquid; Tablet
Tibemid
Indication
For the management of hypertension.
Tibemid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Tibemid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Tibemid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Tibemid
Patient Information
Tibemid
Organisms Affected
Humans and other mammals