Isonikazid
Brand names,
Isonikazid
Analogs
Isonikazid
Brand Names Mixture
Isonikazid
Chemical_Formula
C19H24N2O3
Isonikazid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonikazid
fda sheet
Isonikazid
msds (material safety sheet)
Isonikazid
Synthesis Reference
No information avaliable
Isonikazid
Molecular Weight
328.406 g/mol
Isonikazid
Melting Point
195-196 oC
Isonikazid
H2O Solubility
20 mg/ml (HCl salt)
Isonikazid
State
Solid
Isonikazid
LogP
2.868
Isonikazid
Dosage Forms
Liquid; Tablet
Isonikazid
Indication
For the management of hypertension.
Isonikazid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonikazid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonikazid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonikazid
Patient Information
Isonikazid
Organisms Affected
Humans and other mammals