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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H24N2O3
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RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
328.406 g/mol
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Melting Point
195-196 oC
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H2O Solubility
20 mg/ml (HCl salt)
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State
Solid
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LogP
2.868
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Dosage Forms
Liquid; Tablet
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Indication
For the management of hypertension.
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Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
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Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
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side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
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Patient Information
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Organisms Affected
Humans and other mammals