Isonicotinic hydrazide
Brand names,
Isonicotinic hydrazide
Analogs
Isonicotinic hydrazide
Brand Names Mixture
Isonicotinic hydrazide
Chemical_Formula
C19H24N2O3
Isonicotinic hydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinic hydrazide
fda sheet
Isonicotinic hydrazide
msds (material safety sheet)
Isonicotinic hydrazide
Synthesis Reference
No information avaliable
Isonicotinic hydrazide
Molecular Weight
328.406 g/mol
Isonicotinic hydrazide
Melting Point
195-196 oC
Isonicotinic hydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinic hydrazide
State
Solid
Isonicotinic hydrazide
LogP
2.868
Isonicotinic hydrazide
Dosage Forms
Liquid; Tablet
Isonicotinic hydrazide
Indication
For the management of hypertension.
Isonicotinic hydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinic hydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinic hydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinic hydrazide
Patient Information
Isonicotinic hydrazide
Organisms Affected
Humans and other mammals