Isocotin
Brand names,
Isocotin
Analogs
Isocotin
Brand Names Mixture
Isocotin
Chemical_Formula
C19H24N2O3
Isocotin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isocotin
fda sheet
Isocotin
msds (material safety sheet)
Isocotin
Synthesis Reference
No information avaliable
Isocotin
Molecular Weight
328.406 g/mol
Isocotin
Melting Point
195-196 oC
Isocotin
H2O Solubility
20 mg/ml (HCl salt)
Isocotin
State
Solid
Isocotin
LogP
2.868
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Dosage Forms
Liquid; Tablet
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Indication
For the management of hypertension.
Isocotin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isocotin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isocotin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
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Patient Information
Isocotin
Organisms Affected
Humans and other mammals