Isoniacid
Brand names,
Isoniacid
Analogs
Isoniacid
Brand Names Mixture
Isoniacid
Chemical_Formula
C19H24N2O3
Isoniacid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isoniacid
fda sheet
Isoniacid
msds (material safety sheet)
Isoniacid
Synthesis Reference
No information avaliable
Isoniacid
Molecular Weight
328.406 g/mol
Isoniacid
Melting Point
195-196 oC
Isoniacid
H2O Solubility
20 mg/ml (HCl salt)
Isoniacid
State
Solid
Isoniacid
LogP
2.868
Isoniacid
Dosage Forms
Liquid; Tablet
Isoniacid
Indication
For the management of hypertension.
Isoniacid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isoniacid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isoniacid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isoniacid
Patient Information
Isoniacid
Organisms Affected
Humans and other mammals