Isonicazide
Brand names,
Isonicazide
Analogs
Isonicazide
Brand Names Mixture
Isonicazide
Chemical_Formula
C19H24N2O3
Isonicazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicazide
fda sheet
Isonicazide
msds (material safety sheet)
Isonicazide
Synthesis Reference
No information avaliable
Isonicazide
Molecular Weight
328.406 g/mol
Isonicazide
Melting Point
195-196 oC
Isonicazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicazide
State
Solid
Isonicazide
LogP
2.868
Isonicazide
Dosage Forms
Liquid; Tablet
Isonicazide
Indication
For the management of hypertension.
Isonicazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicazide
Patient Information
Isonicazide
Organisms Affected
Humans and other mammals