Isocotin

GLAXO INC -- LABETALOL HYDROCHLORIDE -- 6505-01-244-7982
=====================  Product Identification  =====================

Product ID:LABETALOL HYDROCHLORIDE
MSDS Date:10/01/1988
FSC:6505
NIIN:01-244-7982
MSDS Number: BWLHM
=== Responsible Party ===
Company Name:GLAXO INC
Address:5 MOORE DR
City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709
Country:US
Info Phone Num:919-248-2354
Emergency Phone Num:919-248-2100/2700
CAGE:34006
=== Contractor Identification ===
Company Name:GLAXO WELLCOME INC.
Address:5 MOORE DR
Box:13398
City:DURHAM
State:NC
ZIP:27709
Country:US
Phone:919-248-2100
CAGE:34006

=============  Composition/Information on Ingredients  =============

Ingred Name:LABETALOL HYDROCHLORIDE
CAS:37780-64-6
Fraction by Wt: 100% %
Other REC Limits:NONE RECOMMENDED
ACGIH TLV:200 UG/M3

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:GLAXO SAFE WORKING LEVEL: 2 MG/M3
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:IRRITATION TO NOSE, THROAT AND LUNGS.
    PROLONGED INHALATION MAY RESULT IN INFLAMMATION, NOSE BLEEDS AND
    PAINFUL BREATHING. SKIN CONTACT MAY CAUSE IRRITATION. PROLONGED
    SKIN CONTACT MAY CAUSE INFLAMMATI ON RESULTING IN RASHES. EYE
    CONTACT CAUSES IRRITATION. INGESTION MAY CAUSE LOWERING OF THE
    BLOOD PRESSURE, DIZZINESS.
Explanation of Carcinogenicity:THIS COMPOUND CONTAINS NO INGREDIENTS AT
    CONCENTRATIONS OF 0.1% OR GREATER THAT ARE CARCINOGENS OR SUSPECT
    CARCINOGENS.
Effects of Overexposure:EYE IRRITATION, SKIN IRRITATION, SKIN RASHS,
    UPPER RESPIRATORY TRACT IRRITATION, NAUSEA, VOMITING, FATIGUE,
    DIZZINESS, LOWERING OF BLOOD PRESSURE.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

=======================  First Aid Measures  =======================

First Aid:EYES: FLUSH WITH WATER FOR 15 MINUTES WHILE HOLDING EYELIDS
    OPEN. GET MEDICAL ATTENTION. SKIN: REMOVE CONTAMINATED CLOTHING.
    WASH WITH SOAP AND WATER. IF IRRITATION PERSISTS, GET MEDICAL
    ATTENTION. IN HALATION: REMOVE TO FRESH AIR. RESTORE BREATHING. GET
    MEDICAL ATTENTION. INGESTION: GIVE COPIOUS AMOUNTS OF WATER AND
    INDUCE VOMITING, IF CONSCIOUS. GET MEDICAL ATTENTION.

=====================  Fire Fighting Measures  =====================

Flash Point:NONFLAMMABLE
Lower Limits:NOT GIVEN
Upper Limits:NOT GIVEN
Extinguishing Media:WATERSPRAY, DRY CHEMICAL, FOAM
Fire Fighting Procedures:FIRE FIGHTERS SHOULD USE NIOSH APPROVED SCBA &
    FULL PROTECTIVE EQUIPMENT WHEN FIGHTING CHEMICAL FIRE. USE WATER
    SPRAY TO COOL NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:AS WITH ANY ORGANIC DUST, THERE IS
    POTENTIAL FOR EXPLOSION WHEN SUSPENDED IN AIR IN HIGH
    CONCENTRATIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:NOTIFY SUPERVISOR. MINIMIZE CONTACT WITH
    SPILLED MATERIAL. USE PROPER PERSONAL PROTECTIVE EQUIPMENT. CONTAIN
    SPILL. STOP LEAK IF CAN DO SO WITHOUT RISK. ABSORB LIQUID WITH
    SUITABLE ABSORBENT MATERIAL.  COLLECT FOR DISPOSAL.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN A COOL, DRY, WELL-VENTILATED
    AREA. USE STORAGE PRACTICES THAT WILL MINIMIZE THE GENERATION OF
    DUST.
Other Precautions:AVOID SKIN CONTACT. LAUNDER CONTAMINATED CLOTHING
    BEFORE REUSE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE FOR CONSUMER PACKAGE, A HALF MASK
    RESPIRATOR WITH ORGANIC VAPOR/ACID GAS/HIGH EFFIENCY CARTRIDGES MAY
    BE USED FOR HANDLING THE MATERIAL IN BULK.
Ventilation:LOCAL EXHAUST AND MECHANICAL (GENERAL) VENTILATION TO
    MAINTAIN EXPOSURE LEVELS.
Protective Gloves:LATEX FOR BULK HANDLING
Eye Protection:SAFETY GLASSES OR GOGGLES
Other Protective Equipment:AN EMERGENCY EYE WASH STATION AND SHOWER
    SHOULD BE AVAILABLE.
Work Hygienic Practices:WASH WITH SOAP AND WATER AFTER HANDLING PRODUCT
    AND BEFORE EATING DRINKING OR SMOKING.
Supplemental Safety and Health
NONE SPECIFIED BY MANUFACTURER.

==================  Physical/Chemical Properties  ==================

HCC:N1
Boiling Pt:B.P. Text:NOT GIVEN
Melt/Freeze Pt:M.P/F.P Text:356F,180C
Vapor Pres:NOT GIVEN
Vapor Density:NOT GIVEN
Spec Gravity:NOT GIVEN
Evaporation Rate & Reference:NOT GIVEN
Solubility in Water:NOT GIVEN
Appearance and Odor:WHITE OR OFF-WHITE CRYSTALLINE POWDER

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NONE SPECIFIED BY MANUFACTURER.
Stability Condition to Avoid:HEAT, OPEN FLAME, HIGH TEMPERATURES
Hazardous Decomposition Products:TOXIC AND/OR CORROSIVE VAPORS
    CONSISTING OF HYDROGEN CHLORIDE AND OXIDES OF NITROGEN.

====================  Disposal Considerations  ====================

Waste Disposal Methods:PREVENT WASTE FROM CONTAMINATING SURROUNDING
    ENVIRONMENT. DISCARD ANY PRODUCT, RESIDUE, DISPOSAL CONTAINER OR
    LINER IN ACCORDANCE WITH ALL FEDERAL, STATE AND LOCAL REGULATIONS.

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 of Defense.  The United States of America in no manner whatsoever,
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 disclaims all liability for its use.  Any person utilizing this
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