Nifdemin
Brand names,
Nifdemin
Analogs
Nifdemin
Brand Names Mixture
Nifdemin
Chemical_Formula
C17H18N2O6
Nifdemin
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifdemin
fda sheet
Nifdemin
msds (material safety sheet)
Nifdemin
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifdemin
Molecular Weight
346.335 g/mol
Nifdemin
Melting Point
172 - 174 oC
Nifdemin
H2O Solubility
Insoluble
Nifdemin
State
Solid
Nifdemin
LogP
2.343
Nifdemin
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifdemin
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifdemin
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifdemin
Absorption
Rapidly and fully absorbed following oral administration.
Nifdemin
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifdemin
Patient Information
Nifdemin
Organisms Affected
Humans and other mammals