Aldipin
Brand names,
Aldipin
Analogs
Aldipin
Brand Names Mixture
Aldipin
Chemical_Formula
C17H18N2O6
Aldipin
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Aldipin
fda sheet
Aldipin
msds (material safety sheet)
Aldipin
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Aldipin
Molecular Weight
346.335 g/mol
Aldipin
Melting Point
172 - 174 oC
Aldipin
H2O Solubility
Insoluble
Aldipin
State
Solid
Aldipin
LogP
2.343
Aldipin
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Aldipin
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Aldipin
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Aldipin
Absorption
Rapidly and fully absorbed following oral administration.
Aldipin
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Aldipin
Patient Information
Aldipin
Organisms Affected
Humans and other mammals