Duranifin
Brand names,
Duranifin
Analogs
Duranifin
Brand Names Mixture
Duranifin
Chemical_Formula
C17H18N2O6
Duranifin
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Duranifin
fda sheet
Duranifin
msds (material safety sheet)
Duranifin
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Duranifin
Molecular Weight
346.335 g/mol
Duranifin
Melting Point
172 - 174 oC
Duranifin
H2O Solubility
Insoluble
Duranifin
State
Solid
Duranifin
LogP
2.343
Duranifin
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Duranifin
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Duranifin
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Duranifin
Absorption
Rapidly and fully absorbed following oral administration.
Duranifin
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Duranifin
Patient Information
Duranifin
Organisms Affected
Humans and other mammals