Tibricol
Brand names,
Tibricol
Analogs
Tibricol
Brand Names Mixture
Tibricol
Chemical_Formula
C17H18N2O6
Tibricol
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Tibricol
fda sheet
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msds (material safety sheet)
Tibricol
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Tibricol
Molecular Weight
346.335 g/mol
Tibricol
Melting Point
172 - 174 oC
Tibricol
H2O Solubility
Insoluble
Tibricol
State
Solid
Tibricol
LogP
2.343
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Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Tibricol
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Tibricol
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Tibricol
Absorption
Rapidly and fully absorbed following oral administration.
Tibricol
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
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Patient Information
Tibricol
Organisms Affected
Humans and other mammals