Introcar
Brand names,
Introcar
Analogs
Introcar
Brand Names Mixture
Introcar
Chemical_Formula
C17H18N2O6
Introcar
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Introcar
fda sheet
Introcar
msds (material safety sheet)
Introcar
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Introcar
Molecular Weight
346.335 g/mol
Introcar
Melting Point
172 - 174 oC
Introcar
H2O Solubility
Insoluble
Introcar
State
Solid
Introcar
LogP
2.343
Introcar
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Introcar
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Introcar
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Introcar
Absorption
Rapidly and fully absorbed following oral administration.
Introcar
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Introcar
Patient Information
Introcar
Organisms Affected
Humans and other mammals