Dilafed
Brand names,
Dilafed
Analogs
Dilafed
Brand Names Mixture
Dilafed
Chemical_Formula
C17H18N2O6
Dilafed
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Dilafed
fda sheet
Dilafed
msds (material safety sheet)
Dilafed
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Dilafed
Molecular Weight
346.335 g/mol
Dilafed
Melting Point
172 - 174 oC
Dilafed
H2O Solubility
Insoluble
Dilafed
State
Solid
Dilafed
LogP
2.343
Dilafed
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Dilafed
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Dilafed
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Dilafed
Absorption
Rapidly and fully absorbed following oral administration.
Dilafed
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Dilafed
Patient Information
Dilafed
Organisms Affected
Humans and other mammals