Cardifen
Brand names,
Cardifen
Analogs
Cardifen
Brand Names Mixture
Cardifen
Chemical_Formula
C17H18N2O6
Cardifen
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cardifen
fda sheet
Cardifen
msds (material safety sheet)
Cardifen
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cardifen
Molecular Weight
346.335 g/mol
Cardifen
Melting Point
172 - 174 oC
Cardifen
H2O Solubility
Insoluble
Cardifen
State
Solid
Cardifen
LogP
2.343
Cardifen
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cardifen
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cardifen
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cardifen
Absorption
Rapidly and fully absorbed following oral administration.
Cardifen
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cardifen
Patient Information
Cardifen
Organisms Affected
Humans and other mammals