Corynphar
Brand names,
Corynphar
Analogs
Corynphar
Brand Names Mixture
Corynphar
Chemical_Formula
C17H18N2O6
Corynphar
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Corynphar
fda sheet
Corynphar
msds (material safety sheet)
Corynphar
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Corynphar
Molecular Weight
346.335 g/mol
Corynphar
Melting Point
172 - 174 oC
Corynphar
H2O Solubility
Insoluble
Corynphar
State
Solid
Corynphar
LogP
2.343
Corynphar
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Corynphar
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Corynphar
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Corynphar
Absorption
Rapidly and fully absorbed following oral administration.
Corynphar
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Corynphar
Patient Information
Corynphar
Organisms Affected
Humans and other mammals