Cordaflex
Brand names,
Cordaflex
Analogs
Cordaflex
Brand Names Mixture
Cordaflex
Chemical_Formula
C17H18N2O6
Cordaflex
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cordaflex
fda sheet
Cordaflex
msds (material safety sheet)
Cordaflex
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cordaflex
Molecular Weight
346.335 g/mol
Cordaflex
Melting Point
172 - 174 oC
Cordaflex
H2O Solubility
Insoluble
Cordaflex
State
Solid
Cordaflex
LogP
2.343
Cordaflex
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cordaflex
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cordaflex
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cordaflex
Absorption
Rapidly and fully absorbed following oral administration.
Cordaflex
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cordaflex
Patient Information
Cordaflex
Organisms Affected
Humans and other mammals