Cordafen
Brand names,
Cordafen
Analogs
Cordafen
Brand Names Mixture
Cordafen
Chemical_Formula
C17H18N2O6
Cordafen
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cordafen
fda sheet
Cordafen
msds (material safety sheet)
Cordafen
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cordafen
Molecular Weight
346.335 g/mol
Cordafen
Melting Point
172 - 174 oC
Cordafen
H2O Solubility
Insoluble
Cordafen
State
Solid
Cordafen
LogP
2.343
Cordafen
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cordafen
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cordafen
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cordafen
Absorption
Rapidly and fully absorbed following oral administration.
Cordafen
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cordafen
Patient Information
Cordafen
Organisms Affected
Humans and other mammals