Nifedine
Brand names,
Nifedine
Analogs
Nifedine
Brand Names Mixture
Nifedine
Chemical_Formula
C17H18N2O6
Nifedine
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifedine
fda sheet
Nifedine
msds (material safety sheet)
Nifedine
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifedine
Molecular Weight
346.335 g/mol
Nifedine
Melting Point
172 - 174 oC
Nifedine
H2O Solubility
Insoluble
Nifedine
State
Solid
Nifedine
LogP
2.343
Nifedine
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifedine
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifedine
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifedine
Absorption
Rapidly and fully absorbed following oral administration.
Nifedine
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifedine
Patient Information
Nifedine
Organisms Affected
Humans and other mammals