Ecodipin
Brand names,
Ecodipin
Analogs
Ecodipin
Brand Names Mixture
Ecodipin
Chemical_Formula
C17H18N2O6
Ecodipin
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Ecodipin
fda sheet
Ecodipin
msds (material safety sheet)
Ecodipin
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Ecodipin
Molecular Weight
346.335 g/mol
Ecodipin
Melting Point
172 - 174 oC
Ecodipin
H2O Solubility
Insoluble
Ecodipin
State
Solid
Ecodipin
LogP
2.343
Ecodipin
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Ecodipin
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Ecodipin
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Ecodipin
Absorption
Rapidly and fully absorbed following oral administration.
Ecodipin
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Ecodipin
Patient Information
Ecodipin
Organisms Affected
Humans and other mammals