Cardilate
Brand names,
Cardilate
Analogs
Cardilate
Brand Names Mixture
Cardilate
Chemical_Formula
C17H18N2O6
Cardilate
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cardilate
fda sheet
Cardilate
msds (material safety sheet)
Cardilate
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cardilate
Molecular Weight
346.335 g/mol
Cardilate
Melting Point
172 - 174 oC
Cardilate
H2O Solubility
Insoluble
Cardilate
State
Solid
Cardilate
LogP
2.343
Cardilate
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cardilate
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cardilate
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cardilate
Absorption
Rapidly and fully absorbed following oral administration.
Cardilate
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cardilate
Patient Information
Cardilate
Organisms Affected
Humans and other mammals