Alpha-Nifedipine Retard
Brand names,
Alpha-Nifedipine Retard
Analogs
Alpha-Nifedipine Retard
Brand Names Mixture
Alpha-Nifedipine Retard
Chemical_Formula
C17H18N2O6
Alpha-Nifedipine Retard
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Alpha-Nifedipine Retard
fda sheet
Alpha-Nifedipine Retard
msds (material safety sheet)
Alpha-Nifedipine Retard
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Alpha-Nifedipine Retard
Molecular Weight
346.335 g/mol
Alpha-Nifedipine Retard
Melting Point
172 - 174 oC
Alpha-Nifedipine Retard
H2O Solubility
Insoluble
Alpha-Nifedipine Retard
State
Solid
Alpha-Nifedipine Retard
LogP
2.343
Alpha-Nifedipine Retard
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Alpha-Nifedipine Retard
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Alpha-Nifedipine Retard
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Alpha-Nifedipine Retard
Absorption
Rapidly and fully absorbed following oral administration.
Alpha-Nifedipine Retard
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Alpha-Nifedipine Retard
Patient Information
Alpha-Nifedipine Retard
Organisms Affected
Humans and other mammals