Fenamon
Brand names,
Fenamon
Analogs
Fenamon
Brand Names Mixture
Fenamon
Chemical_Formula
C17H18N2O6
Fenamon
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Fenamon
fda sheet
Fenamon
msds (material safety sheet)
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Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Fenamon
Molecular Weight
346.335 g/mol
Fenamon
Melting Point
172 - 174 oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
2.343
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Dosage Forms
Capsule; Tablet; Tablet (extended-release)
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Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Fenamon
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Fenamon
Absorption
Rapidly and fully absorbed following oral administration.
Fenamon
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
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Patient Information
Fenamon
Organisms Affected
Humans and other mammals