Adapress
Brand names,
Adapress
Analogs
Adapress
Brand Names Mixture
Adapress
Chemical_Formula
C17H18N2O6
Adapress
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adapress
fda sheet
Adapress
msds (material safety sheet)
Adapress
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adapress
Molecular Weight
346.335 g/mol
Adapress
Melting Point
172 - 174 oC
Adapress
H2O Solubility
Insoluble
Adapress
State
Solid
Adapress
LogP
2.343
Adapress
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adapress
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adapress
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adapress
Absorption
Rapidly and fully absorbed following oral administration.
Adapress
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adapress
Patient Information
Adapress
Organisms Affected
Humans and other mammals