Nifecor
Brand names,
Nifecor
Analogs
Nifecor
Brand Names Mixture
Nifecor
Chemical_Formula
C17H18N2O6
Nifecor
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifecor
fda sheet
Nifecor
msds (material safety sheet)
Nifecor
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifecor
Molecular Weight
346.335 g/mol
Nifecor
Melting Point
172 - 174 oC
Nifecor
H2O Solubility
Insoluble
Nifecor
State
Solid
Nifecor
LogP
2.343
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Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifecor
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifecor
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifecor
Absorption
Rapidly and fully absorbed following oral administration.
Nifecor
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifecor
Patient Information
Nifecor
Organisms Affected
Humans and other mammals