Nifensar XL
Brand names,
Nifensar XL
Analogs
Nifensar XL
Brand Names Mixture
Nifensar XL
Chemical_Formula
C17H18N2O6
Nifensar XL
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifensar XL
fda sheet
Nifensar XL
msds (material safety sheet)
Nifensar XL
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifensar XL
Molecular Weight
346.335 g/mol
Nifensar XL
Melting Point
172 - 174 oC
Nifensar XL
H2O Solubility
Insoluble
Nifensar XL
State
Solid
Nifensar XL
LogP
2.343
Nifensar XL
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifensar XL
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifensar XL
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifensar XL
Absorption
Rapidly and fully absorbed following oral administration.
Nifensar XL
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifensar XL
Patient Information
Nifensar XL
Organisms Affected
Humans and other mammals