Nifelan
Brand names,
Nifelan
Analogs
Nifelan
Brand Names Mixture
Nifelan
Chemical_Formula
C17H18N2O6
Nifelan
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifelan
fda sheet
Nifelan
msds (material safety sheet)
Nifelan
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifelan
Molecular Weight
346.335 g/mol
Nifelan
Melting Point
172 - 174 oC
Nifelan
H2O Solubility
Insoluble
Nifelan
State
Solid
Nifelan
LogP
2.343
Nifelan
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifelan
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifelan
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifelan
Absorption
Rapidly and fully absorbed following oral administration.
Nifelan
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifelan
Patient Information
Nifelan
Organisms Affected
Humans and other mammals