Alonix S
Brand names,
Alonix S
Analogs
Alonix S
Brand Names Mixture
Alonix S
Chemical_Formula
C17H18N2O6
Alonix S
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Alonix S
fda sheet
Alonix S
msds (material safety sheet)
Alonix S
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Alonix S
Molecular Weight
346.335 g/mol
Alonix S
Melting Point
172 - 174 oC
Alonix S
H2O Solubility
Insoluble
Alonix S
State
Solid
Alonix S
LogP
2.343
Alonix S
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Alonix S
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Alonix S
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Alonix S
Absorption
Rapidly and fully absorbed following oral administration.
Alonix S
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Alonix S
Patient Information
Alonix S
Organisms Affected
Humans and other mammals