Nifelate
Brand names,
Nifelate
Analogs
Nifelate
Brand Names Mixture
Nifelate
Chemical_Formula
C17H18N2O6
Nifelate
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifelate
fda sheet
Nifelate
msds (material safety sheet)
Nifelate
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifelate
Molecular Weight
346.335 g/mol
Nifelate
Melting Point
172 - 174 oC
Nifelate
H2O Solubility
Insoluble
Nifelate
State
Solid
Nifelate
LogP
2.343
Nifelate
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifelate
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifelate
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifelate
Absorption
Rapidly and fully absorbed following oral administration.
Nifelate
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifelate
Patient Information
Nifelate
Organisms Affected
Humans and other mammals