Apo-Nifed

Apo-Nifed Brand names, Apo-Nifed Analogs

Apo-Nifed Brand Names Mixture

No information avaliable

Apo-Nifed Chemical_Formula

C₁₇H₁₈N₂O₆

Apo-Nifed RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Apo-Nifed fda sheet

Apo-Nifed FDA

Apo-Nifed msds (material safety sheet)

Apo-Nifed MSDS

Apo-Nifed Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Apo-Nifed Molecular Weight

346.335 g/mol

Apo-Nifed Melting Point

172 - 174 ^oC

Apo-Nifed H₂O Solubility

Insoluble

Apo-Nifed State

Solid

Apo-Nifed LogP

2.343

Apo-Nifed Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Apo-Nifed Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Apo-Nifed Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Apo-Nifed Absorption

Rapidly and fully absorbed following oral administration.

Apo-Nifed side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Apo-Nifed Patient Information

Apo-Nifed Organisms Affected

Humans and other mammals