Coracten
Brand names,
Coracten
Analogs
Coracten
Brand Names Mixture
Coracten
Chemical_Formula
C17H18N2O6
Coracten
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Coracten
fda sheet
Coracten
msds (material safety sheet)
Coracten
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Coracten
Molecular Weight
346.335 g/mol
Coracten
Melting Point
172 - 174 oC
Coracten
H2O Solubility
Insoluble
Coracten
State
Solid
Coracten
LogP
2.343
Coracten
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Coracten
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Coracten
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Coracten
Absorption
Rapidly and fully absorbed following oral administration.
Coracten
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Coracten
Patient Information
Coracten
Organisms Affected
Humans and other mammals