Bonacid
Brand names,
Bonacid
Analogs
Bonacid
Brand Names Mixture
Bonacid
Chemical_Formula
C17H18N2O6
Bonacid
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Bonacid
fda sheet
Bonacid
msds (material safety sheet)
Bonacid
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Bonacid
Molecular Weight
346.335 g/mol
Bonacid
Melting Point
172 - 174 oC
Bonacid
H2O Solubility
Insoluble
Bonacid
State
Solid
Bonacid
LogP
2.343
Bonacid
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Bonacid
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Bonacid
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Bonacid
Absorption
Rapidly and fully absorbed following oral administration.
Bonacid
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Bonacid
Patient Information
Bonacid
Organisms Affected
Humans and other mammals