Citilat
Brand names,
Citilat
Analogs
Citilat
Brand Names Mixture
Citilat
Chemical_Formula
C17H18N2O6
Citilat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Citilat
fda sheet
Citilat
msds (material safety sheet)
Citilat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Citilat
Molecular Weight
346.335 g/mol
Citilat
Melting Point
172 - 174 oC
Citilat
H2O Solubility
Insoluble
Citilat
State
Solid
Citilat
LogP
2.343
Citilat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Citilat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Citilat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Citilat
Absorption
Rapidly and fully absorbed following oral administration.
Citilat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Citilat
Patient Information
Citilat
Organisms Affected
Humans and other mammals