Cordilan

Cordilan Brand names, Cordilan Analogs

Cordilan Brand Names Mixture

No information avaliable

Cordilan Chemical_Formula

C₁₇H₁₈N₂O₆

Cordilan RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Cordilan fda sheet

Cordilan FDA

Cordilan msds (material safety sheet)

Cordilan MSDS

Cordilan Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Cordilan Molecular Weight

346.335 g/mol

Cordilan Melting Point

172 - 174 ^oC

Cordilan H₂O Solubility

Insoluble

Cordilan State

Solid

Cordilan LogP

2.343

Cordilan Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Cordilan Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Cordilan Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Cordilan Absorption

Rapidly and fully absorbed following oral administration.

Cordilan side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Cordilan Patient Information

Cordilan Organisms Affected

Humans and other mammals