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Niphedipine Brand names, Niphedipine Analogs

Niphedipine Brand Names Mixture

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Niphedipine Chemical_Formula


Niphedipine RX_link

Niphedipine fda sheet

Niphedipine FDA

Niphedipine msds (material safety sheet)

Niphedipine MSDS

Niphedipine Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Niphedipine Molecular Weight

346.335 g/mol

Niphedipine Melting Point

172 - 174 oC

Niphedipine H2O Solubility


Niphedipine State


Niphedipine LogP


Niphedipine Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Niphedipine Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Niphedipine Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Niphedipine Absorption

Rapidly and fully absorbed following oral administration.

Niphedipine side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)

Niphedipine Patient Information

Niphedipine Organisms Affected

Humans and other mammals