Adalat Ft
Brand names,
Adalat Ft
Analogs
Adalat Ft
Brand Names Mixture
Adalat Ft
Chemical_Formula
C17H18N2O6
Adalat Ft
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat Ft
fda sheet
Adalat Ft
msds (material safety sheet)
Adalat Ft
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat Ft
Molecular Weight
346.335 g/mol
Adalat Ft
Melting Point
172 - 174 oC
Adalat Ft
H2O Solubility
Insoluble
Adalat Ft
State
Solid
Adalat Ft
LogP
2.343
Adalat Ft
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat Ft
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat Ft
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat Ft
Absorption
Rapidly and fully absorbed following oral administration.
Adalat Ft
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat Ft
Patient Information
Adalat Ft
Organisms Affected
Humans and other mammals