Cardionorm
Brand names,
Cardionorm
Analogs
Cardionorm
Brand Names Mixture
Cardionorm
Chemical_Formula
C17H18N2O6
Cardionorm
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cardionorm
fda sheet
Cardionorm
msds (material safety sheet)
Cardionorm
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cardionorm
Molecular Weight
346.335 g/mol
Cardionorm
Melting Point
172 - 174 oC
Cardionorm
H2O Solubility
Insoluble
Cardionorm
State
Solid
Cardionorm
LogP
2.343
Cardionorm
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cardionorm
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cardionorm
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cardionorm
Absorption
Rapidly and fully absorbed following oral administration.
Cardionorm
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cardionorm
Patient Information
Cardionorm
Organisms Affected
Humans and other mammals