Adalat LP
Brand names,
Adalat LP
Analogs
Adalat LP
Brand Names Mixture
Adalat LP
Chemical_Formula
C17H18N2O6
Adalat LP
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat LP
fda sheet
Adalat LP
msds (material safety sheet)
Adalat LP
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat LP
Molecular Weight
346.335 g/mol
Adalat LP
Melting Point
172 - 174 oC
Adalat LP
H2O Solubility
Insoluble
Adalat LP
State
Solid
Adalat LP
LogP
2.343
Adalat LP
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat LP
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat LP
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat LP
Absorption
Rapidly and fully absorbed following oral administration.
Adalat LP
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat LP
Patient Information
Adalat LP
Organisms Affected
Humans and other mammals