Hadipin
Brand names,
Hadipin
Analogs
Hadipin
Brand Names Mixture
Hadipin
Chemical_Formula
C17H18N2O6
Hadipin
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Hadipin
fda sheet
Hadipin
msds (material safety sheet)
Hadipin
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Hadipin
Molecular Weight
346.335 g/mol
Hadipin
Melting Point
172 - 174 oC
Hadipin
H2O Solubility
Insoluble
Hadipin
State
Solid
Hadipin
LogP
2.343
Hadipin
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Hadipin
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Hadipin
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Hadipin
Absorption
Rapidly and fully absorbed following oral administration.
Hadipin
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Hadipin
Patient Information
Hadipin
Organisms Affected
Humans and other mammals