Hexadilat
Brand names,
Hexadilat
Analogs
Hexadilat
Brand Names Mixture
Hexadilat
Chemical_Formula
C17H18N2O6
Hexadilat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Hexadilat
fda sheet
Hexadilat
msds (material safety sheet)
Hexadilat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Hexadilat
Molecular Weight
346.335 g/mol
Hexadilat
Melting Point
172 - 174 oC
Hexadilat
H2O Solubility
Insoluble
Hexadilat
State
Solid
Hexadilat
LogP
2.343
Hexadilat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Hexadilat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Hexadilat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Hexadilat
Absorption
Rapidly and fully absorbed following oral administration.
Hexadilat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Hexadilat
Patient Information
Hexadilat
Organisms Affected
Humans and other mammals