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Aprical Brand names, Aprical Analogs

Aprical Brand Names Mixture

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Aprical Chemical_Formula


Aprical RX_link


Aprical fda sheet

Aprical FDA

Aprical msds (material safety sheet)

Aprical MSDS

Aprical Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Aprical Molecular Weight

346.335 g/mol

Aprical Melting Point

172 - 174 oC

Aprical H2O Solubility


Aprical State


Aprical LogP


Aprical Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Aprical Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Aprical Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Aprical Absorption

Rapidly and fully absorbed following oral administration.

Aprical side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)

Aprical Patient Information

Aprical Organisms Affected

Humans and other mammals