Adalat Crono
Brand names,
Adalat Crono
Analogs
Adalat Crono
Brand Names Mixture
Adalat Crono
Chemical_Formula
C17H18N2O6
Adalat Crono
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat Crono
fda sheet
Adalat Crono
msds (material safety sheet)
Adalat Crono
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat Crono
Molecular Weight
346.335 g/mol
Adalat Crono
Melting Point
172 - 174 oC
Adalat Crono
H2O Solubility
Insoluble
Adalat Crono
State
Solid
Adalat Crono
LogP
2.343
Adalat Crono
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat Crono
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat Crono
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat Crono
Absorption
Rapidly and fully absorbed following oral administration.
Adalat Crono
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat Crono
Patient Information
Adalat Crono
Organisms Affected
Humans and other mammals