Adalat LA
Brand names,
Adalat LA
Analogs
Adalat LA
Brand Names Mixture
Adalat LA
Chemical_Formula
C17H18N2O6
Adalat LA
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat LA
fda sheet
Adalat LA
msds (material safety sheet)
Adalat LA
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat LA
Molecular Weight
346.335 g/mol
Adalat LA
Melting Point
172 - 174 oC
Adalat LA
H2O Solubility
Insoluble
Adalat LA
State
Solid
Adalat LA
LogP
2.343
Adalat LA
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat LA
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat LA
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat LA
Absorption
Rapidly and fully absorbed following oral administration.
Adalat LA
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat LA
Patient Information
Adalat LA
Organisms Affected
Humans and other mammals