Anpine
Brand names,
Anpine
Analogs
Anpine
Brand Names Mixture
Anpine
Chemical_Formula
C17H18N2O6
Anpine
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Anpine
fda sheet
Anpine
msds (material safety sheet)
Anpine
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Anpine
Molecular Weight
346.335 g/mol
Anpine
Melting Point
172 - 174 oC
Anpine
H2O Solubility
Insoluble
Anpine
State
Solid
Anpine
LogP
2.343
Anpine
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Anpine
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Anpine
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Anpine
Absorption
Rapidly and fully absorbed following oral administration.
Anpine
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Anpine
Patient Information
Anpine
Organisms Affected
Humans and other mammals