Calcibloc

Calcibloc Brand names, Calcibloc Analogs

Calcibloc Brand Names Mixture

No information avaliable

Calcibloc Chemical_Formula

C₁₇H₁₈N₂O₆

Calcibloc RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Calcibloc fda sheet

Calcibloc FDA

Calcibloc msds (material safety sheet)

Calcibloc MSDS

Calcibloc Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Calcibloc Molecular Weight

346.335 g/mol

Calcibloc Melting Point

172 - 174 ^oC

Calcibloc H₂O Solubility

Insoluble

Calcibloc State

Solid

Calcibloc LogP

2.343

Calcibloc Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Calcibloc Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Calcibloc Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Calcibloc Absorption

Rapidly and fully absorbed following oral administration.

Calcibloc side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Calcibloc Patient Information

Calcibloc Organisms Affected

Humans and other mammals