Nifedepat
Brand names,
Nifedepat
Analogs
Nifedepat
Brand Names Mixture
Nifedepat
Chemical_Formula
C17H18N2O6
Nifedepat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifedepat
fda sheet
Nifedepat
msds (material safety sheet)
Nifedepat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifedepat
Molecular Weight
346.335 g/mol
Nifedepat
Melting Point
172 - 174 oC
Nifedepat
H2O Solubility
Insoluble
Nifedepat
State
Solid
Nifedepat
LogP
2.343
Nifedepat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifedepat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifedepat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifedepat
Absorption
Rapidly and fully absorbed following oral administration.
Nifedepat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifedepat
Patient Information
Nifedepat
Organisms Affected
Humans and other mammals