Alfadal
Brand names,
Alfadal
Analogs
Alfadal
Brand Names Mixture
Alfadal
Chemical_Formula
C17H18N2O6
Alfadal
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Alfadal
fda sheet
Alfadal
msds (material safety sheet)
Alfadal
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Alfadal
Molecular Weight
346.335 g/mol
Alfadal
Melting Point
172 - 174 oC
Alfadal
H2O Solubility
Insoluble
Alfadal
State
Solid
Alfadal
LogP
2.343
Alfadal
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Alfadal
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Alfadal
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Alfadal
Absorption
Rapidly and fully absorbed following oral administration.
Alfadal
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Alfadal
Patient Information
Alfadal
Organisms Affected
Humans and other mammals