Chronadalate Lp
Brand names,
Chronadalate Lp
Analogs
Chronadalate Lp
Brand Names Mixture
Chronadalate Lp
Chemical_Formula
C17H18N2O6
Chronadalate Lp
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Chronadalate Lp
fda sheet
Chronadalate Lp
msds (material safety sheet)
Chronadalate Lp
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Chronadalate Lp
Molecular Weight
346.335 g/mol
Chronadalate Lp
Melting Point
172 - 174 oC
Chronadalate Lp
H2O Solubility
Insoluble
Chronadalate Lp
State
Solid
Chronadalate Lp
LogP
2.343
Chronadalate Lp
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Chronadalate Lp
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Chronadalate Lp
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Chronadalate Lp
Absorption
Rapidly and fully absorbed following oral administration.
Chronadalate Lp
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Chronadalate Lp
Patient Information
Chronadalate Lp
Organisms Affected
Humans and other mammals