Nifelat
Brand names,
Nifelat
Analogs
Nifelat
Brand Names Mixture
Nifelat
Chemical_Formula
C17H18N2O6
Nifelat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifelat
fda sheet
Nifelat
msds (material safety sheet)
Nifelat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifelat
Molecular Weight
346.335 g/mol
Nifelat
Melting Point
172 - 174 oC
Nifelat
H2O Solubility
Insoluble
Nifelat
State
Solid
Nifelat
LogP
2.343
Nifelat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifelat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifelat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifelat
Absorption
Rapidly and fully absorbed following oral administration.
Nifelat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifelat
Patient Information
Nifelat
Organisms Affected
Humans and other mammals