Glopir
Brand names,
Glopir
Analogs
Glopir
Brand Names Mixture
Glopir
Chemical_Formula
C17H18N2O6
Glopir
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Glopir
fda sheet
Glopir
msds (material safety sheet)
Glopir
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Glopir
Molecular Weight
346.335 g/mol
Glopir
Melting Point
172 - 174 oC
Glopir
H2O Solubility
Insoluble
Glopir
State
Solid
Glopir
LogP
2.343
Glopir
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Glopir
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Glopir
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Glopir
Absorption
Rapidly and fully absorbed following oral administration.
Glopir
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Glopir
Patient Information
Glopir
Organisms Affected
Humans and other mammals